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13 The latest meta-analysis shows that AN adult patients have an average reduction of 0.16 kg in whole-body bone mineral content, 14 and there is no gender difference in the reduction of BMD in adolescent patients, 15 In terms of bone microstructure, abnormalities are observed in the distal radius and distal tibia of AN patients, manifested as reduced volumetric bone mineral density (vBMD), decreased cortical bone area and thickness, increased porosity, decreased trabecular bone density and increased separation degree, but the results of studies on trabecular bone number changes are inconsistent

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While they both use semaglutide, theyre prescribed for different reasons and follow different dosing schedules

Hence, subsequent trials administered GDNF through either parenchymal infusions into the striatum 48 or via gene therapy to transfect the host, but with overall negative results 10,40,50

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